The nervous system is anatomically formed by the Central Nervous System (CNS), which includes the brain and spinal cord, and by the Peripheral Nervous System (PN), which includes the cranial nerves that branch out from the brain and the spinal nerves emerging from the spinal cord. The theory that everything dies and nothing regenerates in the nervous system has kept most scientists and therapists away from studying and using cephalic recovery; today, on the other hand, it is known that there is more plasticity at the level of the nervous system than previously thought and how changes induced in occlusion are matched by nerve microstructural modifications, both in adults and children. There is a peripheral interdependence and a relationship with the central nervous system (CNS) , so whatever the structure involved (the TMJ, the occlusion or the muscles of the jaw), there is an action on the whole; the stronger the physiological stimulus at the peripheral level (therefore at the level of occlusion), the greater the effects on the central nervous system (CNS) . Neurologically, the teeth function as detection sensors for activating a program, chewing. Under each individual dental element there are receptors that send information to the brain for proper chewing. When we talk about the mouth, we are talking about a part of our body that carries out important vital functions in extension and in close connection with the posture and with the central nervous system (CNS) that can over time influence our behavior, our mood up to also affect our psyche. To understand all this, it is necessary to examine the essential characteristics of the functional organization of the elements that make up the nervous system, of which the receptors are an integral part. There are sensory systems capable of collecting resonance information when excited which determine a functional organization of the central nervous system (CNS) . The mouth with its occlusion and all that includes the stomatognathic system will have a spatial informational role through stable dental contacts in relation to the craniosacral system that will serve as neurological reference positions in extension with vast amounts of important information that will be processed by the brain, limbic system and the neocortex. AMCOP Bio Activators, through the elastic effect of the materials used, are able to provide important stimuli that provide information that reaches the brain by developing a specific electromagnetic energy emitted by the brain itself. AMCOP Bio Activators are considered true sensorineural transmitters. A fundamental study on the properties of the sensory system concerns the mechanism with the physical aspects of suitable stimuli that are transformed into nerve messages. AMCOP Bio Activators are multifunctional orthodontic devices that have thermoelastic thermo-activatable characteristics that allow a specifically vibrational informational resonance action on the whole body through the transmission of a well-defined energy procured by specific stimulation exercises by the patient in association with the extraordinarily plastic effect of the materials used. Functional orthodontic devices (designed and manufactured in Bari), therefore, in addition to being comfortable and gentle orthodontic therapeutic tools to align the teeth, are also harmonizers of the mouth by restoring a correct occlusion and rehabilitating the psyche.